Serum lidocaine concentration after epidural administration in dogs

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Serum lidocaine concentration after epidural administration in dogs

The pharmacokinetics of lidocaine deals with the measurement of lidocaine concentration in the blood and its changes over time. The toxicity of lidocaine is a function of its peak plasma concentration, which in turn depends on several factors including total dose and rates of systemic absorption and elimination. The aim of the study was to assess serum levels of lidocaine after a single shot ep...

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Lidocaine concentration in cerebrospinal fluid after epidural administration: a comparison between epidural and combined spinal-epidural anesthesia.

BACKGROUND In this study, lidocaine concentrations in cerebrospinal fluid (CSF) at different interspaces were measured with or without preceding spinal anesthesia, 10 min after epidural injection of lidocaine, to investigate the effects of preceding meningeal puncture on CSF concentrations of epidurally administered local anesthetic. METHODS Sixty patients scheduled to receive combined spinal...

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Postmortem redistribution of lidocaine after epidural injection in beagle dogs.

OBJECTIVES An animal model using beagle dog has been established to investigate the postmortem redistribution of lidocaine. MATERIALS AND METHODS 18 dogs were euthanized and injected lidocaine (13 mg/kg) via epidural immediately. An autopsy was performed at 0, 12, 24, 48, 72, 96 hours after drug administration. All animals were stored in supine position at room temperature. For the other grou...

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Effect of Epidural Anesthesia with Lidocaine and Bupivacaine on Gastrointestinal Transit Time in Healthy Dogs

Objective- To evaluate the effect of epidural anesthesia with lidocaine and bupivacaine on transit time of barium sulfate contrast medium through gastrointestinal (GI) tracts in healthy dogs. Design- Prospective, randomized experimental study. Animals-Five healthy mixed breed male dogs with 19.2±7.8 months age and 19.9±3.3 kg weight Procedure- The animals received one of the treatments of sa...

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Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs

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ژورنال

عنوان ژورنال: Veterinární Medicína

سال: 2012

ISSN: 0375-8427,1805-9392

DOI: 10.17221/5569-vetmed